GHRP-6 - 5mg

STRUCTURE

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys

Molecular Formula: C46H56N12O6

Molecular Weight: 873.032 g/mol

CAS Number: 87616-84-0

Peptide Purity: Greater than 98%.

Other details: No TFA Salt

Storage: Lyophilized peptide must be stored at -20°C and peptide solution at 4°C.

DESCRIPTION

GHRP-6 (Growth Hormone Releasing Peptide-6) is a powerful stimulator of the natural release of growth hormone from the anterior pituitary gland. This peptide acts as an agonist of the ghrelin receptor, a hormone involved in metabolism, appetite regulation, and several essential biological processes. Its mechanism of action has made GHRP-6 a focus of research for its numerous benefits, ranging from neuroprotection to tissue regeneration and improved sexual function.

MECHANISM OF ACTION

Ghrelin Receptor Stimulation (GHS-R1a)

• By binding to ghrelin receptors, GHRP-6 promotes the release of growth hormone (GH), resulting in enhanced cellular regeneration, lipid metabolism, and muscle development.
• Activation of these receptors also has neuroprotective, antioxidant, and anti-apoptotic effects.

Regulation of GH Release

• GH stimulated by GHRP-6 supports protein synthesis, tissue regeneration, and glucose metabolism, contributing to overall health.

Interaction with CD36 Receptor

• This receptor promotes blood vessel growth and tissue repair, making GHRP-6 effective in wound treatment and skin improvement.

KEY BENEFITS OF GHRP-6

Memory Enhancement and Brain Tissue Protection

GHRP-6 has shown significant neuroprotective properties due to its interaction with ghrelin receptors in the central nervous system.

• Memory Enhancement: Facilitates long-term memory formation by promoting synaptic plasticity and reducing oxidative stress in neurons. Improves communication between brain cells, aiding learning and memory processes.
• Protection in Neurodegenerative Disorders: Reduces programmed cell death (apoptosis) in neurons. Activation of ghrelin receptors decreases inflammation and oxidative damage in the brain.

Protection of Neurons in Parkinson’s Disease

A 2018 study revealed that ghrelin receptors are present in the substantia nigra, an area of the brain severely affected by Parkinson’s disease.

• Reduction in Receptor Expression: In Parkinson’s patients or those with a genetic predisposition, ghrelin receptor expression on substantia nigra neurons is reduced. Animal models with this defect display Parkinson-like symptoms when a ghrelin antagonist is injected.
• Role of GHRP-6: As a ghrelin receptor agonist, GHRP-6 may compensate for the reduced receptor activity. It minimizes neuron apoptosis in the substantia nigra, potentially slowing or preventing Parkinson’s progression.

Skin Improvement and Wound Healing

GHRP-6 enhances cellular survival by reducing programmed cell death and promoting tissue regeneration. It is particularly effective in preventing hypertrophic scars and keloids, improving the quality of wound healing.

• Wound Healing: By interacting with the CD36 receptor, GHRP-6 stimulates new blood vessel growth (angiogenesis) at wound sites. Speeds up skin regeneration and accelerates tissue repair.
• Anti-Aging for Skin: Maintains skin tone and elasticity through increased collagen production, driven by GH release.

Cardiac Cell Protection

GHRP-6 has demonstrated cardioprotective effects by preventing oxidative damage to heart muscle cells.

• Reduction of Oxidative Cytotoxicity: Shields cardiac cells from damage caused by free radicals. Reduces the risk of heart failure under oxidative stress conditions.
• Cardiac Regeneration: Enhances the survival of myocardial cells, supporting the repair of damaged cardiac tissue.

Motivation and Sexual Desire

Ghrelin receptors in the central nervous system play a key role in regulating sexual behavior and motivation.

• Increased Sexual Motivation: Elevated ghrelin levels, induced by GHRP-6, enhance sexual drive and reward-seeking behavior.
• Behavioral Modulation: Animal studies show that activating ghrelin receptors in specific brain regions positively influences sexual behavior and motivation.

REFERENCES

T.Lei et al., "Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells" [PubMed]

A. Lania et al., "Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types" [PubMed]

R.J. DeVita "Small molecule mimetics of GHRP-6" [PubMed]

M.H. Borges et al., "Different effects of growth hormone releasing peptide (GHRP-6) and GH-releasing hormone on GH release in endogenous and exogenous hypercortisolism" [PubMed]

V. Popovic et al., "Evaluation of pituitary GH reserve with GHRP-6" [PubMed]

F.R. Pimentel-Filho et al., "Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism" [PubMed]

R.M. Frieboes et al., "Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man" [PubMed]

K.m. Fairhall et al., "Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.