Thymosin Alpha-1 is a natural regulator of immune function. It has since been studied for cystic fibrosis, infection (e.g. tuberculosis, cytomegalovirus), respiratory disorders, chronic hepatitis, and cancer. Thymosin alpha-1 was first discovered in 1972 and was isolated from tissue of the thymus gland and is a potent immune function modulator.



Sequence: Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Molecular Formula: C129H215N33O55

Molecular Weight: 3108-315 g/mol

CAS number: 62304-98-7

Peptide purity: greater than 98%

Other details: No TFA Salt

Storage: Lyophilized peptide must be stored at -20°C and peptide solution at 4°C. 

Tesamorelin has low oral and excellent subcutaneous bioavailability.


Thymosin alpha-1, first isolated from tissue of the thymus gland, is a potent regulator of immune function. The thymus is responsible for making T-cells and for ensuring that they mature properly. T-cells are some of the most important parts of the adaptive immune system, where they help the immune system remember past infections and improve the function of other immune system cells to boost their ability to fight infection.

Research in mice without thymus glands shows that thymosin alpha-1 alone is enough to restore immune function and prevent widespread infection. The peptide works at the most fundamental levels of the immune system to activate signaling pathways and stimulate the production of cytokines and other molecules that help to coordinate the activities of various cells in the immune system. In other words, thymosin alpha-1 has broad, positive effects on the immune system.

One way in which thymosin alpha-1 may be of benefit is in vaccine construction. Right now, many vaccines consist of inactivated (killed) pathogens because administering live pathogens, even when they are weakened, is risky. Unfortunately, inactivated vaccines are less effective and thus immunity is not as great. Thymosin alpha-1 may solve this problem by boosting the response of the immune system to inactivated vaccines. The net results would include not only boosted immunity, but longer duration of immunity. This may be of benefit, particularly in the setting of severe disease like avian influenza, HIV, and more.

Another way in which the ability of thymosin alpha-1 to regulate the immune system may be of benefit is in the setting of sepsis. Sepsis is a life-threatening condition caused by an over-inflated immune response to infection. The ability to regulate the immune response in this setting could save lives and prevent organ damage. Research suggests that thymosin alpha-1 lowers mortality in patients with sepsis and reduced long-term complications. Though ongoing research is needed, the early results suggest that thymosin alpha-1 may soon be approved as an adjuvant therapy for sepsis.


A. Dominari et al., "Thymosin alpha 1: A comprehensive review of the literature" [PubMed]

C.D. Ancell et al., "Thymosin alpha-1" [PubMed]

R. King et al., "Immune Modulation with Thymosin Alpha 1 Treatment" [PubMed]

E. Garaci et al., "Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application" [PubMed]

Y. Liu et al., "Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells" [PubMed]

C. Matteucci et al., "Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 Patients" [PubMed]

J. Liu et al., "Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study" [PubMed]

X. Wang et al., "Thymosin alpha 1 is associated with improved cellular immunity and reduced infection rate in severe acute pancreatitis patients in a double-blind randomized control study" [PubMed]

L. Romani et al., "Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling" [PubMed]

C. Shao et al., "Thymosin alpha-1-transformed Bifidobacterium promotes T cell proliferation and maturation in mice by oral administration" [PubMed]


This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. 

All product information provided on this website is for informational and educational purposes only.

Data sheet


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