MELANOTAN 2 - 10mg

STRUCTURE

Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)

Molecular Formula: C50H69N15O9

Molecular Weight: 1024.198 g/mol

CAS Number: 121062-08-6

Peptide purity: Greater than 98%

No TFA salt

Storage: Lyophilized peptide must be stored at -20°C and peptide solution at +4°C.

DESCRIPTION

Melanotan 2 interacts with the melanocortin receptor system to exert its biological effects. This involves a preferential binding to the MC-4R and MC-1R receptors, as well as a lesser affinity for the MC-3R receptor, among the five identified types of melanocortin receptors, each responsible for different physiological functions.

MC-1R: Located in melanocytes, the activation of this receptor is crucial for increasing the pigmentation of the skin and hair.

MC-2R: Found in the adrenal glands, its stimulation promotes the release of adrenal hormones such as cortisol, which are essential for stress response and metabolism.

MC-3R: This receptor plays a role in regulating appetite and energy balance, though its function is less understood compared to the other receptors.

MC-4R: Its activation affects eating and sexual behavior, as well as playing a role in male erectile function and energy management.

MC-5R: Expressed primarily on sweat glands and pancreatic islet cells, indicating the broad spectrum of Melanotan 2's action beyond skin pigmentation.

Melanotan 2 (MT-2) has emerged as a peptide of interest within the scientific community due to its wide-ranging effects on human physiology and behavior. Originally synthesized to mimic the body’s naturally occurring alpha-melanocyte-stimulating hormone (α-MSH), MT-2 has shown potential benefits far beyond its initial application for skin tanning. This article delves into the scientific exploration of MT-2, highlighting its interactions and benefits across various domains, including sexual arousal, skin pigmentation, compulsive behavior, addiction, appetite regulation, glucagon production, and Autism Spectrum Disorder (ASD) characteristics.

Enhancing Sexual Arousal

MT-2 has been studied for its effects on sexual function, particularly its ability to enhance sexual arousal. The peptide's mechanism involves binding to melanocortin receptors, notably the MC-4R, which plays a significant role in the modulation of sexual behavior. Research has demonstrated that MT-2 can effectively increase sexual desire and arousal, offering potential therapeutic benefits for sexual dysfunctions.

Promoting Skin Tanning and Pigmentation

The primary function of MT-2 is to stimulate melanogenesis, the process of melanin production, leading to skin darkening. By activating the MC-1R receptor on melanocytes, MT-2 mimics the natural tanning process without the need for UV exposure, providing a protective layer against sun-induced skin damage and potentially reducing the risk of skin cancer.

Reducing Compulsive Behavior and Controlling Addiction

MT-2's interaction with the melanocortin system has implications for the modulation of compulsive behaviors and addiction. By influencing pathways associated with reward and pleasure, MT-2 may offer avenues for managing conditions characterized by compulsive actions, including substance dependence. Preliminary studies suggest that MT-2 could help in reducing alcohol intake and curbing behaviors linked to addiction.

Combating Hunger and Appetite Regulation

Another notable effect of MT-2 is its influence on appetite and food intake. By acting on melanocortin receptors involved in satiety signals, MT-2 has the potential to suppress hunger, thereby aiding in weight management and combating obesity. This effect is particularly relevant in the context of the growing global obesity epidemic and the search for effective treatments.

Reducing Glucagon Production

In the realm of metabolic health, MT-2 has shown promise in its ability to regulate glucagon production. Glucagon, a hormone that raises blood glucose levels, plays a critical role in diabetes management. By modulating the activity of melanocortin receptors, MT-2 may contribute to better glycemic control, offering benefits for individuals with diabetes by potentially reducing the need for exogenous insulin.

Reversing Characteristics of Autism Spectrum Disorder

One of the most intriguing potential applications of MT-2 is in the treatment of ASD. Recent research indicates that MT-2 may ameliorate some autistic behaviors in animal models, such as social interaction deficits and repetitive behaviors, possibly through the modulation of oxytocin pathways. These findings open new research avenues for understanding ASD and developing targeted therapies.

Melanotan 2 stands at the frontier of peptide research, offering a spectrum of potential benefits that extend well beyond its original use for skin tanning. Its effects on sexual arousal, skin pigmentation, compulsive behavior, addiction, appetite regulation, glucagon production, and ASD characteristics underscore the peptide's multifunctional nature. As research progresses, the therapeutic applications of MT-2 may expand, heralding new treatments for a range of conditions. 

REFERENCES

E. Gilhooley et al., "Melanotan II User Experience: A Qualitative Study of Online Discussion Forums" [PubMed]

R.T. Dorr et al., "Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study"[PubMed]

H. Wessells et al., "Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study" [PubMed]

E. Minakova et al., "Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism" [PubMed]

P. Werkwejt et al., "Melanotan-II reverses memory impairment induced by a short-term HF diet" [PubMed]

H. Wessells et al., "Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II" [PubMed]

N.L. Eliason et al.,"Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.