Obesity

5-amino-1MQ is a small molecule that inhibits the activity of an enzyme known as nicotinamide N-methyltransferase (NNMT). NNMT plays a significant role in metabolism and energy, primarily active in adipose tissue. By blocking NNMT, 5-amino-1MQ triggers an increase in nicotinamide adenine dinucleotide (NAD+), a core cofactor for cellular metabolism, thereby boosting the metabolic rate and activating a gene called sirtuin-1 (SIRT1), also referred to as the 'longevity gene. Here are the key benefits: - Inhibition of NNMT, an enzyme involved in metabolism and energy - Increase in NAD+, a crucial cofactor for cellular metabolism - Activation of the sirtuin-1 (SIRT1) gene, also known as the 'longevity gene. - Potential reduction in the risk of various health conditions, including diabetes, obesity, metabolic syndrome, cardiovascular diseases - Reduction in body mass without changes in food intake.

AOD9604 is a modified form of the hGH fragment 176-191 peptide that has a di-sulfide bridge (hGH). AOD9604, a substance that was first created as a lipolytic (fat-burning) agent, has shown promise in trials of cardiac disease, osteoarthritis/cartilage repair, and metabolic syndrome. In animal research, AOD9604 promotes lipolysis and prevents lipogenesis, which are two processes that break down or destroy fat. - Reduces body fat - Increases calorie burn - Triggers fat release - Boosts your metabolism - Prevents non-fatty foods from turning into body fat - May help with bone and cartilage repair, especially when used with the peptide BPC 157

Growth hormone and insulin-like growth factor 1 are both produced in greater amounts in the blood when CJC-1295, a synthetic equivalent of growth hormone releasing hormone (GHRH), is taken (IGF-1). The plasma half-life of CJC-1295 may be extended thanks to an additional molecule known as DAC. It has been shown to have the effects that are listed below: - Increases lean body mass and protein synthesis - Reduced body fat.

Modified GRF is a truncated peptide analogue of growth hormone releasing hormone (GHRH). It has been shown to have the following effects: - Improves muscle repair and growth - Accelerates wound healing - Strengthens bones - Increases fat burning - Improves metabolism. - It may also have beneficial effects on blood sugar regulation and the immune system.

- Stimulates lipolysis, which results in a reduction of abdominal fat  - Boosts energy and vigor  - Tightens skin - Riddings wrinkles - Increases endurance - Improves sleep quality - Raise the overall percentage of lean body mass.

GW 0742 is a potent and highly selective PPARδ agonist.  Research has shown that GW-0742 has the following benefits: – Significantly increases resistance to physical exertion – Drastically improves aerobic performance – Extremely effective for fat loss – Improves lipid profiles  – Regulates blood sugar (antidiabetic effect) – Anti inflammatory properties

Increased energy, muscle building potential, insulin sensitivity, fat burning potential, endurance, and improved lipid profiles are the most notable benefits that GW-501516  has exhibited in testing via its selective activation of PPARδ.

HGH Fragment 176-191 is a fragment of natural human growth hormone that has been chemically synthesized (HGH). Because of its capacity to hasten the breakdown of fat, it is sometimes referred to as the "lipolysis fragment." It has been proven to help decrease blood sugar levels and accelerate cartilage repair without boosting long-bone development, raising IGF-1 levels, or modifying insulin sensitivity. These benefits may be achieved without affecting the body's ability to respond to insulin. HGH FRAG 176-191 has a significant influence on the following: - Energy level and endurance - Strengthens ligaments, joints, and bone tissue, which makes the skin seem better; improves the overall appearance of the body - The increase in lean muscle mass as a result of an indirect and catabolic action that suppresses lipogenesi - Stimulates lipolysis activity, leading to increased fat loss

IGF-1 LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia. It has been demonstrated that: - It is a potential treatment of growth hormone IGF-1 deficiency - Decreases body fat - Increases metabolism - Increases bone density - It is a potential treatment of muscle dystrophy and diabetes - Contributes to the growth of a healthy, lean muscle mass

It has been shown that ipamorelin has effects on: - Increased lean muscle mass - Reduction in total body fat - Sleep improvement - Increased level of IGF-1 - Increased bone mineral content - Enhanced capacity for the repair and regeneration of individual cells - Increased in the synthesis of collagen - Protection against the catabolic effects of glucocorticoids

LGD-4033 is a selective androgen receptor modulator (SARM) currently being researched for its potential applications in the clinical treatment of muscle wasting, osteoporosis and other related conditions. LGD-4033 is purported to be the most potent SARM currently in clinical trials, with its data exhibiting the most favorable ratio of anabolic activity relative to androgenic activity.

Melanotan-2 exhibits several notable effects, including: Promoting skin pigmentation for tanning Enhancing sexual arousal Suppressing appetite Reducing compulsive behaviors Decreasing glucagon production Potentially alleviating autism-related features Aiding in addiction control

The mitochondrial-derived peptide MOTS-c enhances exercise capacity and lowers obesity, insulin resistance, and other disease processes including osteoporosis while promoting metabolic homeostasis and life. - According to research, MOTS-c is helpful for the following: - Muscle Metabolism - Fat Metabolism - Insulin Sensitivity - Osteoporosis - Longevity - Heart Health

Pegylated Mechano Growth Factor (PEG MGF) is a subtype of IGF-1 (insulin-like growth factor-1), which promotes the division of myoblasts and permits the fusion and maturation of muscle fibers. The following therapeutic benefits of PEG-MGF have been shown through research: - Ability to re-build muscles - Ability to make new muscle cells - Neuroprotective effects - Cardioprotective effects - Promotes wound healing and tissue regeneration - Promotes bone injury recovery - Lowers total body fat and cholesterol - Increases immunity

Retatrutide is a peptide characterized as a triple GGG agonist, targeting three key incretin receptors: GLP-1R (Glucagon-Like Peptide-1 Receptor), GIPR (Gastric Inhibitory Peptide Receptor), and GCGR (Glucagon Receptor). This multifaceted approach allows retatrutide to exert a comprehensive influence on metabolic processes, including enhancing satiety signals, slowing gastric emptying, and increasing the breakdown of stored fats and glycogen.

Semaglutide is a modified form of the naturally present GLP-1 peptide, which is recognized for its ability to regulate blood sugar and boost insulin release. Studies indicate that Semaglutide could also have positive effects on cardiac, hepatic, and pulmonary health, as well as potentially mitigating the impact of Alzheimer's disease. Additionally, it has been found to effectively curb hunger by slowing down the emptying of the stomach and limiting the movement of the intestines. As a GLP-1 analog, it is designed to both enhance insulin production and inhibit the release of glucagon in a manner dependent on glucose levels. Semaglutide has demonstrated the largest weight loss of any obesity medication to date with reductions of approximately 15% of initial weight at 68 weeks.

Setmelanotide works by activating pathways in the brain to promote weight loss by decreasing appetite and caloric intake, and increasing energy expenditure.

Tesamorelin, is a growth-hormone-releasing hormone (GHRH) analogue. Recent research and clinical trials have established that it has the following benefits: - Increases natural productions of HGH (human growth hormone) - Increases IGF-1 (Insulin Growth Factor – 1) without altering glucose parameters - Reduced triglycerides - Reduced Visceral Adipose Tissue (VAT) - Reduced Carotid Intima Media Size (cIMT) - Improved cognition in adults over the age of 60 - Anti-aging  effects - Restoring Growth Hormone - Preserving Lean Muscle Mass Tesamorelin is now being tested in clinical trials for the treatment of HIV-associated lipodystrophy. (Lipodystrophy is characterized by excessive accumulation of fat not just in the abdominal region but also in other parts of the body.) It is also being researched for its ability to improve peripheral nerve health and slow the progression of mild cognitive impairment/dementia.

Tesofensine significantly supports weight loss, body fat reduction, and appetite reduction. It increases an individual's resting energy expenditure by stimulating the fat oxidation process. Below are its main effects: - Reduced body fat / Weight loss - Appetite suppression - Improved libido - Better sleep quality - Improved cognitive function

Developed primarily to combat type 2 diabetes, Tirzepatide is a synthetic form of gastric inhibitory polypeptide (GIP) that also possesses glucagon-like peptide-1 (GLP-1) functionality. This dual action enables it to not only reduce blood sugar levels and enhance insulin sensitivity but also promote weight loss and increase feelings of fullness. Moreover, Tirzepatide has demonstrated protective effects on the cardiovascular system.

TRH (thyrotropin releasing hormone) is a small peptide hormone produced in the hypothalamus. Research on TRH has shown improvement in thyroid function as well as multiple other effects: - Antidepressant activity - Aging-Reversing - Free radical reduction - Regulation of the autonomic nervous system - Loss of fat deposits - Lowering of sugar and triglyceride levels