MELANOTAN 1 - 10mg

STRUCTURE

Sequence: Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val

Molecular Formula: C78H111N21O19

Molecular Weight: 1646.874 g/mol

CAS Number: 75921-69-6

Peptide purity: Greater than 98%

No TFA salt

Storage: Lyophilized peptide must be stored at -20°C and peptide solution at +4°C.

DESCRIPTION

Melanotan 1 (MT-1) is a synthetic peptide that shares similarities with the natural alpha-melanocyte-stimulating hormone (alpha-MSH). Initially developed as a sunless tanning agent, MT-1 has shown a range of effects beyond skin pigmentation, including sexual arousal, appetite regulation, and metabolic changes. This article delves into the various research findings on MT-1, exploring its potential applications in medicine and its mechanisms of action.

Melanotan 1 and Skin Pigmentation

• Similarity to Alpha-MSH: MT-1 is closely related to alpha-MSH, differing by only one amino acid.
• Receptor Binding: Both MT-1 and alpha-MSH bind to melanocortin receptors, particularly MC1, which is responsible for skin and hair pigmentation.
• Tanning Effects: Clinical trials have shown that MT-1 increases the likelihood of tanning and reduces the risk of sunburn.

Beyond Skin Pigmentation: Additional Effects

• Sexual Arousal: MT-1 has been found to increase sexual arousal.
• Appetite and Metabolism: The peptide also affects appetite and basic metabolic rates.

Applications

• Vitiligo Treatment: MT-1, in combination with UVB light therapy, has shown promise in treating vitiligo.
• Actinic Keratosis: Research is underway to explore MT-1's potential in treating precancerous skin lesions.
• High Blood Pressure: In hypertensive mice, MT-1 has shown protective effects against high blood pressure.

Neuroprotective Effects

• Alzheimer's Disease: Studies in mice suggest that MT-1 could protect against cognitive decline and Alzheimer's disease.
• Multiple Sclerosis: MT-1 has been found to prevent myelin loss in neurons, offering potential benefits in treating multiple sclerosis.

Mechanisms of Action

• MC4 Receptor: MT-1's effects on T cells and inflammation are mediated through the MC4 receptor.
• MC5 Receptor: The peptide also acts on the MC5 receptor, affecting fat storage and oxidation.

Conclusion

Melanotan 1 is a multifaceted peptide with a range of potential therapeutic applications. While initially developed for skin tanning, its effects on various physiological pathways make it a subject of ongoing research.

REFERENCES

R.T. Dorr et al., "Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers" [PubMed]

S.O. Ugwu et al., "Skin pigmentation and pharmacokinetics of melanotan-I in humans" [PubMed]

N. Surendran et al., "High-performance liquid chromatographic assay for Melanotan-1 ([Nle4-DPhe7]alpha-melanocyte-stimulating hormone) in biological matrices" [PubMed]

L.M. Fitzgerald et al., "Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles" [PubMed]

M.E. Hadley et al., "Discovery and development of novel melanogenic drugs. Melanotan-I and -II" [PubMed]

R.T. Dorr "Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

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