EPITALON - 10ml/200mg - Spray

ADVANCED DELIVERY SYSTEM – CELL PENETRATING PEPTIDE TECHNOLOGY

This product utilizes advanced delivery technology incorporating calibrated cell-penetrating peptide (CPP) systems. The formulation is engineered to support efficient and targeted intracellular delivery of active ingredients, contributing to enhanced transport performance and bioavailability.

SPECIFICATIONS

Product Code: EPI200S

Sequence: Ala-Glu-Asp-Gly

Molecular Formula: C14H22N4O9

Molecular Weight: 390.349 g/mol

CAS Number: 307297-39-8

Purity: Technical / Research Grade ≥98%

Other Details: No TFA Salt

Form: Liquid solution

Appearance: Clear to slightly opalescent

Total Content: 10 mL / 200 mg

Concentration: 20 mg/mL

Approximate Sprays per Bottle: ~82

Approximate Peptide per Spray: ~2,44 mg

Vehicle / Carrier System: Proprietary carrier system

Storage Temperature: 4°C (Do not freeze)

Source: Synthetic

Safety Classification: Standard laboratory handling

DESCRIPTION

Epitalon is a short synthetic tetrapeptide that has been extensively investigated in experimental and preclinical research settings for its interaction with melatonin regulation pathways, telomerase-associated mechanisms, and cellular aging processes. Originally developed in Russia in the 1980s, Epitalon has been studied in animal models where it was associated with modulation of age-related biological parameters.

In vitro investigations in human somatic cells have reported experimental evidence suggesting that Epitalon exposure may influence telomerase-related activity. Telomerase is involved in telomere maintenance, a key factor in chromosomal stability and genomic integrity. Experimental modulation of telomerase-associated pathways has been studied in the context of cellular lifespan regulation and DNA replication fidelity.

Observed effects in experimental systems are not solely explained by telomere maintenance or oxidative stress modulation. Ongoing research therefore continues to examine potential influences on gene expression networks and regulatory pathways involved in long-term cellular function.

Multiple preclinical studies have explored Epitalon’s interaction with immune-related signaling and adaptive responses to physiological stress. These findings are consistent with its proposed role as a regulatory peptide rather than a direct pharmacological effector.

Experimental rodent models have reported associations between Epitalon exposure and increased interferon-gamma expression in aged lymphocytes. Interferon-gamma is a signaling molecule involved in immune regulation and cellular communication.

Research literature describes gene-level interactions observed in experimental systems, including:

• Telomerase-related genes associated with cellular lifespan regulation
• CD5, involved in immune cell differentiation pathways
• IL-2, associated with leukocyte activity regulation
• MMP2, linked to extracellular matrix remodeling
• Tram1, involved in protein synthesis processes
• Arylalkylamine-N-acetyltransferase (AANAT), associated with melatonin synthesis
• pCREB-related signaling pathways involved in circadian regulation

Experimental models have also examined Epitalon’s association with MMP2-related pathways and fibroblast activity. Fibroblasts play a role in extracellular matrix structure, including collagen and elastin production, which has prompted continued investigation in aging-related models.

Additional laboratory findings indicate that Epitalon exposure may be associated with modulation of caspase-3-related pathways in experimental systems. Caspase-3 participates in apoptotic signaling, and its regulation has been studied in cellular viability research contexts.

In oncological research models, Epitalon administration has been evaluated in relation to tumor development dynamics and metastatic behavior. These findings remain confined to experimental and preclinical settings.

Experimental evidence further suggests that Epitalon may influence expression of circadian-related genes such as PER1 in hypothalamic tissue. Circadian gene regulation is closely linked to melatonin synthesis and broader neuroendocrine rhythms.

Animal model research indicates that Epitalon exposure may influence melatonin synthesis through modulation of AANAT and pCREB-associated transcription pathways within the pineal gland. These mechanisms are central to circadian regulation of melatonin release.

Additional experimental investigations have explored Epitalon in retinal degeneration models, where structural and functional observations have been reported in preclinical systems.

REFERENCES

All information presented above is derived from in vitro experiments, animal studies, and other preclinical research models. These data are intended solely for scientific investigation and do not imply any therapeutic or clinical application.

V. Khavinson et al., "Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa" [PubMed]

I.A. Vinogradova et al., "Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes" [PubMed]

T.A. Dzhokhadze et al., "[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)]" [PubMed]

I.N. Alimova et al., "Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice" [PubMed]

N.S. Lin'Kova et al., "Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging" [PubMed]

D.A. Sibarov et al., "Epitalon influences pineal secretion in stress-exposed rats in the daytime" [PubMed]

N.S. Lin'Kova et al., "Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro" [PubMed]

I.F. Labunets et al., "Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people" [PubMed]

D.A. Sibarov et al., "Effects of intranasal administration of epitalon on neuron activity in the rat neocortex" [PubMed]

V.N. Anisimov et al., "Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice" [PubMed]

G. Kossoy et al., "Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice" [PubMed]

N.I. Chasilova et al., "Short peptides stimulate skin cell regeneration during ageing" [PubMed]

O.V. Korkushko et al., "Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people" [PubMed]

V.K. Khavinson et al., "Effect of regulatory peptides on gene transcription" [Springer Nature Link]

V. Khavinson et al., "AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism" [PubMed]

V.N. Anisimov et al., "Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice" [PubMed]

G. Kossoy et al., "Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa" [PubMed]

V.N. Anisimov et al., "Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice" [PubMed]

V.K. Khavinson et al., "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells" [PubMed]

V.N. Anisimov et al., "Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats" [PubMed]

V.K. Khavinson et al., "Short cell-penetrating peptides: a model of interactions with gene promoter sites" [PubMed]

V. Khavinson et al., "Peptide Epitalon activates chromatin at the old age" [Europe PMC]

DISCLAIMER

This product is intended strictly for laboratory research and development use only. It is not a medicine, pharmaceutical product, or dietary supplement. It has not been evaluated or approved by the FDA, EMA, or any other regulatory authority for the prevention, treatment, or diagnosis of any disease.

Bodily introduction into humans or animals is strictly prohibited. This product must be handled exclusively by qualified laboratory professionals in controlled research environments.

All information provided on this website is for scientific and educational purposes only.