IGF-1 LR3 - 1mg

SPECIFICATIONS

Product Code: I1L001

Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

Molecular Formula: C400H625N111O115S9

Molecular Weight: 9117.5 g/mol

CAS: 946870-92-4

Purity: Technical / Research Grade 98%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

IGF-1 LR3 is a synthetic analog of insulin-like growth factor-1 (IGF-1), structurally modified to exhibit reduced binding affinity to IGF-binding proteins and extended persistence in circulation under research conditions. These modifications contribute to an altered pharmacokinetic profile compared to native IGF-1. It is studied for its interaction with IGF-related signaling pathways, which play a central role in cellular communication, regulatory processes, and coordinated biological responses. IGF-1 LR3 is involved in signaling mechanisms associated with cell regulation, intercellular communication, and pathway-specific activation within complex biological systems.

At the molecular level, IGF-1 LR3 interacts with receptor-mediated pathways that initiate intracellular signaling cascades, including pathways associated with gene expression, cellular coordination, and regulatory signaling networks. These processes are studied in controlled environments to better understand system-wide biological responses. Due to its structural modifications and extended activity profile, IGF-1 LR3 is widely used in research models investigating signaling dynamics, growth factor interactions, and integrative regulatory mechanisms across multiple tissue systems.

Its role in cellular signaling and regulatory coordination makes it a compound of interest in advanced experimental models focused on multi-system biological processes and pathway-specific investigations.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

"Growth hormone, athletic performance, and aging" [Harvard Health Publishing]

S. Yakar et al., "40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton" [Journal of Molecular Endocrinology]

"Recombinant Human Insulin-Like Growth Factor (rhIGF-1) Treatment of Short Stature Associated With IGF-1 Deficiency" [ClinicalTrials]

S. Gehmert et al., "Adipose tissue-derived stem cell secreted IGF-1 protects myoblasts from the negative effect of myostatin" [PubMed]

By Mayo Clinic Staff "Human growth hormone (HGH): Does it slow aging?" [Mayo Clinic]

F.M. Tomas et al., "Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats" [PMC]

L.J. Anderson et al., "Use of Growth Hormone, IGF-I, and Insulin for Anabolic Purpose: Pharmacological Basis, Methods of Detection, and Adverse Effects" [PMC]

W.E. Sonntag et al., "Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies" [The Journal of Gerontology]

S. Mohan et al., "IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms" [PubMed]

B. Assefa et al., "Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes" [PMC]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.