MIF-1 - 100mg

SPECIFICATIONS

Product Code: MI1100

Sequence: Pro-Leu-Gly

Molecular Formula: C13H24N4O3

Molecular weight: 284,36 g/mol

CAS: 2002-44-0

Purity: Technical / Research Grade ≥98%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

Melanocyte-Inhibiting Factor 1 (MIF-1) is a short peptide that has been extensively studied in experimental and preclinical research due to its relevance in central nervous system biology. MIF-1 is a tripeptide composed of the amino acids L-proline, L-leucine, and L-glycine, arranged in the sequence Pro-Leu-Gly. It was originally identified for its ability to inhibit melanocyte-stimulating hormone activity; however, subsequent research has revealed that MIF-1 is involved in a broader range of physiological and neurobiological processes. Experimental findings have associated MIF-1 with modulation of mood-related pathways, cognitive function, and neuronal protection, making it a peptide of interest in neurological and neuropsychiatric research.

Effects on the Nervous System

MIF-1 has been shown in research models to exert notable effects on the nervous system, particularly through its interaction with neurotransmitter signaling pathways. Experimental evidence indicates that MIF-1 can influence both dopaminergic and serotonergic systems. By interacting with dopamine receptors, MIF-1 appears to modulate dopaminergic signaling, a process relevant to motor coordination, motivation, and emotional regulation. In addition, its interaction with serotonin-related pathways has been explored in studies examining mood regulation. Together, these modulatory effects suggest a role for MIF-1 in maintaining neurochemical balance within the central nervous system under experimental conditions.

Effects on the Brain

Within the brain, MIF-1 has demonstrated relevance in studies focused on neuroplasticity and neuronal integrity. Research suggests that MIF-1 is capable of crossing the blood–brain barrier, allowing it to interact directly with neural tissue. Experimental observations have associated MIF-1 with enhanced synaptic plasticity, a fundamental process underlying learning, memory formation, and adaptive brain function. In addition, MIF-1 has been studied for its potential neuroprotective properties, including its association with reduced neuronal damage in models involving oxidative stress and neuroinflammatory challenges. These findings have positioned MIF-1 as a molecule of interest in research related to brain resilience and long-term neural maintenance.

Other Effects on Neuroregeneration, Mood Regulation, and Cognitive Function

MIF-1 has also been investigated for its involvement in neuroregenerative processes. Experimental studies suggest that it may support mechanisms related to neuronal repair and cellular renewal, which are relevant in models of neural injury and age-related neurological decline. In the context of mood regulation, MIF-1’s interaction with dopaminergic and serotonergic pathways has been examined in research models addressing emotional balance and stress-related behaviors.

Cognitive function is another area of active investigation. By influencing neuroplasticity and supporting neuronal integrity, MIF-1 has been associated in experimental settings with processes related to memory, attention, and information processing. These combined effects have contributed to scientific interest in MIF-1 as a modulator of higher-order brain functions.

Research Relevance in Degenerative Conditions

The diverse biological activities associated with MIF-1 have made it a peptide of interest in research exploring neurodegenerative conditions. In experimental models related to Parkinson’s disease, MIF-1’s interaction with dopaminergic signaling and neuronal protection pathways has been examined in relation to motor and neural function. In Alzheimer’s disease research models, MIF-1 has been studied for its association with neuroregenerative and anti-inflammatory mechanisms relevant to cognitive decline. Additionally, its effects on mood-related pathways have been explored in studies addressing the psychological and behavioral aspects often associated with neurodegenerative disorders.

Conclusion

MIF-1 is a small peptide with broad relevance in neuroscience research. Its documented interactions with neurotransmitter systems, association with neuroplasticity, involvement in neuroregenerative processes, and relationship to neuronal protection have positioned it as a valuable molecule for experimental investigation. Ongoing research continues to explore the mechanisms through which MIF-1 influences central nervous system function and its potential relevance in studies of neurodegeneration, mood regulation, and cognitive processes.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

R.S. Khan et al., "Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1)" [PubMed]

J.M. Lee et al., "Cyclo(Leu-Gly) has opposite effects on D-2 dopamine receptors in different brain areas" [PubMed]

M. Gonce et al., "Physiological trials with MIF-I in Parkinson's disease" [PubMed]

A. Carolei et al., "MIF (melanocyte-stimulating hormone release-inhibiting factor) and Parkinson's disease" [PubMed]

L.G. Miller et al., "MIF-1 and Tyr-MIF-1 augment GABA-stimulated benzodiazepine receptor binding" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

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