CHONLUTEN - 50mg

SPECIFICATIONS

Product Code: CHO050

Sequence: Glu-Asp-Gly

Molecular Formula: C11H17N3O8

Molecular Weight: 319.27 g/mol

CAS: 75007-24-8

Purity: Technical / Research Grade 98%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

Chonluten is a short synthetic peptide investigated in preclinical research models for its ability to modulate gene expression and epigenetic signaling pathways under experimental conditions. Studies suggest that its activity is tissue-selective, with a predominant focus on pulmonary tissue models, while secondary effects have been explored in gastrointestinal experimental systems.

Gene expression and epigenetic regulation research (preclinical)

In cell culture and animal models, Chonluten has been examined for its influence on transcriptional regulation of genes associated with inflammatory signaling, oxidative stress responses, and cellular proliferation. Short peptides such as Chonluten are used in experimental biology to explore how peptide–DNA and peptide–chromatin interactions may affect gene expression, including mechanisms related to epigenetic modulation and DNA accessibility.

Computational and modeling studies support the hypothesis that short peptides may enter both cytoplasmic and nuclear compartments, allowing them to interact with regulatory regions of the genome and influence the expression of multiple gene networks simultaneously.

Pulmonary tissue and mucosal biology models (preclinical)

Chonluten has been investigated primarily in preclinical pulmonary models to study mucosal biology, extracellular matrix organization, and epithelial response to inflammatory stress. Experimental findings suggest that gene expression patterns associated with mucus production, barrier integrity, and tissue remodeling may be altered under laboratory conditions following peptide exposure.

These models are used to explore how lung-specific gene regulation contributes to mucosal stability and adaptive responses during experimentally induced inflammation or hypoxic stress.

Inflammatory and antioxidant signaling pathways (preclinical)

In laboratory studies, Chonluten has been associated with modulation of genes involved in inflammatory and antioxidant pathways, including transcription factors and stress-response proteins commonly used as markers in experimental biology. These include pathways related to c-Fos–associated signaling, heat shock protein expression, superoxide dismutase activity, and cyclooxygenase- and cytokine-related regulatory systems.

The regulation of these genes is examined to understand how cells coordinate stress adaptation, survival signaling, and redox balance under controlled experimental conditions.

Cellular stress and hypoxia research (preclinical)

Chonluten has also been studied in cellular stress and low-oxygen experimental models to investigate how short peptides influence adaptive transcriptional responses during hypoxic or inflammatory challenges. These systems are used to characterize cellular resilience mechanisms rather than functional or performance outcomes.

Gastrointestinal experimental models (preclinical)

In addition to pulmonary research, Chonluten has been examined in preclinical gastrointestinal models to study vascular signaling, inflammatory gene expression, and mucosal responses under experimentally induced stress conditions. These studies focus on comparative tissue responses and shared regulatory pathways between pulmonary and gastrointestinal mucosa.

REFERENCES

All information presented above is derived from in vitro experiments, animal studies, and other preclinical research models. These data are intended solely for basic scientific investigation of biological mechanisms and do not imply any therapeutic, diagnostic, preventive, or clinical use in humans or animals.

V. Khavinson et al., "Peptide Regulation of Gene Expression: A Systematic Review" [PubMed]

V. Khavinson et al., "Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins" [Bulletin of experimental biology and medicine]

V. Khavinson et al., "Short Peptides Regulate Gene Expression" [PubMed]

L.I. Fedoreyeva et al., "Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA" [PubMed]

V.N. Anisimov, V. Khavinson "Peptide bioregulation of aging: results and prospects" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.