GHK-CU - 200mg

SPECIFICATIONS

Product Code: GHC200

Sequence: Gly-His-Lys (GHK)

Complex: Copper(II) Complex

Molecular Formula: C14H24N6O4Cu

Molecular Weight: ~403.9 g/mol

CAS: 49557-75-7

Purity: Technical / Research Grade ≥98%

Other Details: No TFA Salt

Form: Lyophilized powder

Color: Blue

Storage Temperature: -20°C

Source: Synthetic

Safety Classification: Standard laboratory handling

DESCRIPTION

GHK-Cu, also known as the copper tripeptide, is a naturally occurring human peptide complex composed of glycine, histidine, and lysine bound to copper. Circulating levels of endogenous GHK-Cu have been reported to decline with age, a phenomenon observed in parallel with reductions in tissue regenerative capacity in biological systems.

Experimental investigations across multiple laboratories have associated GHK-Cu with a broad range of biological activities in research settings. These include involvement in wound-healing processes, immune cell recruitment, antioxidant and anti-inflammatory signaling, stimulation of collagen and glycosaminoglycan synthesis in dermal fibroblasts, and support of angiogenesis-related pathways.

Gene-expression analyses indicate that GHK-Cu may influence the regulation of numerous genes associated with tissue remodeling, cellular defense, and extracellular matrix maintenance. These findings suggest a broad modulatory role at the molecular level under experimental conditions.

Cosmetic and Skin Research Applications

GHK-Cu has been extensively studied in dermatological and cosmetic research. Controlled topical studies have reported associations with improvements in skin firmness, elasticity, wrinkle appearance, and overall skin quality. Histological evaluations in research contexts have indicated increased collagen markers and enhanced keratinocyte proliferation following topical exposure.

• Improved skin elasticity and firmness
• Increased dermal density markers
• Reduction in the appearance of fine lines
• Improved skin clarity and tone uniformity
• Enhanced keratinocyte proliferation

Hair Follicle Research

GHK-Cu and related analogues have been studied in experimental models examining hair follicle biology. Some laboratory findings suggest stimulation of pathways involved in follicular activity and dermal papilla signaling.

Cancer-Related Research

In vitro studies have reported that GHK-Cu may influence gene expression patterns associated with metastatic behavior in colon cancer models. These observations support investigation of the peptide as a regulator of multiple biochemical pathways in experimental oncology research.

Stem Cell and Regenerative Research

Laboratory studies have demonstrated that GHK-Cu stimulates keratinocyte proliferation and increases expression of integrins and p63 protein in epidermal stem cells. Since p63 is associated with stem cell function, these findings suggest potential involvement in regenerative signaling pathways under experimental conditions.

Nerve Regeneration Research

Experimental models have reported associations between GHK exposure and increased expression of nerve growth-related factors, integrins, and regeneration of myelinated nerve fibers when delivered via collagen-based systems.

Fibroblast and Cellular Stress Research

In vitro investigations indicate that GHK-Cu may support recovery of human fibroblasts exposed to oxidative or radiation-related stress. These observations suggest involvement in cellular repair and defense mechanisms.

Inflammation and Wound Repair Research

Wound-healing models involve coordinated inflammatory signaling, cell proliferation, migration, and extracellular matrix remodeling. In laboratory studies, GHK-Cu reduced TNF-α–induced IL-6 secretion in dermal fibroblasts, indicating modulation of inflammatory pathways.

DNA Repair Research

Experimental data suggest that GHK may restore viability in irradiated fibroblast models. These findings support investigation into DNA repair-related and genomic regulatory pathways under laboratory conditions.

Overall, extensive experimental literature associates GHK-Cu with dermal repair, tissue remodeling, antioxidant regulation, and gene-expression modulation. All observations described above originate from in vitro systems, animal studies, or other preclinical research contexts and are intended exclusively for scientific investigation.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

L. Pickart et al., "GHK-Cu may Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes" [MDPI]

M. Kukowska et al., "In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections" [PubMed]

L. Pickart et al., "The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health" [PubMed]

L. Pickart et al., "Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data" [PubMed]

A. Gruchlik et al., "Effect of GLY-HIS-LYS and its copper complex on TGF-β secretion in normal human dermal fibroblasts" [PubMed]

L. Pickart et al., "GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration" [BioMed Research International]

S.O. Canapp Jr et al., "The effect of topical tripeptide-copper complex on healing of ischemic open wounds" [PubMed]

X. Wang et al., "GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis" [PubMed]

G.D. Mulder et al., "Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-l-histidyl-l-lysine copper" [PubMed]

L. Pickart et al., "The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline" [PubMed]

L. Pickart et al., "GHK and DNA: Resetting the Human Genome to Health" [BioMed Research International]

DISCLAIMER

This product is intended strictly for laboratory research and development use only. This material is not a medicine or drug and has not been approved by the FDA, EMA, or any regulatory authority for the prevention, treatment, or cure of any disease. Bodily introduction into humans or animals is strictly prohibited. Handling is restricted to qualified laboratory professionals.

All product information provided on this website is for informational and educational purposes only.