HGH FRAGMENT 176-191 - 5mg

SPECIFICATIONS

Product Code: H11005

Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1812.12 g/mol

CAS: 66004-57-7

Purity: Technical / Research Grade 98%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

HGH Fragment (176–191) is a synthetic peptide corresponding to the C-terminal sequence of human growth hormone. It is derived from amino acids 176 to 191 and represents a functionally distinct region of the full-length hormone. This fragment is studied for its selective interaction with signaling pathways associated with metabolic regulation, particularly those involved in lipid-related processes. Due to its truncated structure, it exhibits a more targeted activity profile compared to full-length HGH, allowing investigation into pathway-specific signaling mechanisms.

Research has indicated that this peptide interacts with regulatory processes associated with adipose tissue signaling and metabolic coordination. Its activity appears to be mediated through mechanisms distinct from those of full-length HGH, enabling researchers to study differential pathway activation within complex metabolic systems. Unlike the full hormone, HGH Fragment (176–191) is characterized by a reduced interaction with growth-related signaling pathways, making it relevant for experimental models focused on selective metabolic signaling rather than broad endocrine effects.

Studies also explore its involvement in cellular signaling networks related to energy balance, regulatory coordination, and tissue-level communication processes. These investigations contribute to a broader understanding of how specific peptide fragments influence multi-system metabolic pathways. Due to its selective signaling profile and well-defined structural origin, HGH Fragment (176–191) remains a key compound of interest in advanced research models investigating targeted metabolic regulation and integrative physiological mechanisms

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

R. Ferrer-Lorente et al., "Combined effects of oleoyl-estrone and a beta3-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats" [PubMed]

F.M. Ng, J. Bornstein "Hyperglycemic action of synthetic C-terminal fragments of human growth hormone" [PubMed]

M.A. Heffernan et al. "Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment" [PubMed]

M.M. Habibullah et al., "Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells" [PMC]

J.E. Brinkman et al., "Physiology, Growth Hormone" [PubMed]

V.S. Ayyar "History of growth hormone therapy" [PubMed]

C.S. Reh et al., "Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review" [PubMed]

K. Smith et al., "Treatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174" [PMC]

G.Y.W. Ma et al., "The mechanism of the hyperglycaemic action of synthetic peptides related to the C-terminal sequence of human growth hormone" [ScienceDirect]

L. Napolitano et al., "Growth hormone enhances thymic function in HIV-1–infected adults" [PMC]

M. Plana et al., "The reconstitution of the thymus in immunosuppressed individuals restores CD4-specific cellular and humoral immune responses" [PMC]

J. Svensson et al., "Long-term efficacy and safety of somatropin for adult growth hormone deficiency" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.