GHK - 50mg

SPECIFICATIONS

Product Code: GHK050

Sequence: Gly-His-Lys

Molecular Formula: C14H24N6O4

Molecular Weight: 340.384 g/mol

CAS: 49557-75-7

Purity: Technical / Research Grade 98%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring tripeptide identified in human plasma and also present in biological fluids such as saliva and urine. Since its discovery, GHK has been extensively examined in experimental and laboratory research for its involvement in multiple biological processes.

Scientific investigations indicate that GHK participates in the modulation of gene expression and cellular signaling pathways associated with tissue maintenance, repair mechanisms, and protective responses. For this reason, the peptide has attracted considerable attention in research areas related to skin biology, tissue regeneration, and cellular homeostasis.

Effects on Tissue Repair

In experimental settings, GHK has been studied for its role in tissue repair processes involving skin, hair follicles, gastrointestinal lining, and bone tissue. Laboratory data suggest that GHK may influence the production of collagen, glycosaminoglycans, and extracellular matrix components essential for normal tissue architecture.

Cellular models have shown that GHK can support fibroblast and keratinocyte migration and proliferation, which are fundamental processes in tissue remodeling and structural maintenance. These findings have positioned GHK as a molecule of interest in wound-healing and regenerative biology research.

Effects on Inflammatory Signaling and Fibrinogen Regulation

Research indicates that GHK may interact with inflammatory signaling pathways, including mechanisms involving interleukin-6 (IL-6), a cytokine associated with fibrinogen synthesis. Experimental observations suggest that GHK may influence fibrinogen-related pathways under laboratory conditions, generating interest in vascular and inflammation-related research contexts.

Effects on DNA Repair-Related Gene Expression

Accumulation of DNA damage is linked to cellular dysfunction and aging. Experimental gene expression studies have shown that GHK may modulate pathways associated with DNA repair processes. In laboratory models, this activity has been explored in the context of genomic stability and cellular stress responses.

Effects on the Ubiquitin-Proteasome System

The ubiquitin-proteasome system (UPS) plays a central role in intracellular protein quality control. Experimental data suggest that GHK may influence aspects of proteasome-related activity in cell-based models. Proper UPS function is essential for maintaining protein balance and cellular homeostasis.

Effects on Insulin and IGF-1 Signaling Pathways

GHK has also been investigated for potential interactions with insulin and insulin-like growth factor (IGF-1) signaling pathways in gene expression analyses. Laboratory observations suggest possible modulation of components within these metabolic pathways. These findings remain confined to experimental research settings.

Conclusion

GHK is a biologically active tripeptide that has demonstrated multiple effects in experimental and preclinical research models. Its involvement in tissue remodeling, inflammatory signaling modulation, genomic maintenance, protein turnover systems, and metabolic pathway regulation makes it a compound of ongoing scientific interest.

All described observations originate from laboratory, cellular, or exploratory research and are intended solely for research and educational purposes. Further investigation is required to clarify detailed mechanisms and potential research applications.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications.

L. Pickart et al., "GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration" [PubMed]

Y. Dou et al., "The potential of GHK as an anti-aging peptide" [PubMed]

L. Pickart, "The human tri-peptide GHK and tissue remodeling" [PubMed]

L. Pickart et al., "The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health" [PubMed]

L. Pickart et al., "The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline" [PubMed]

L. Pickart et al., "GHK and DNA: resetting the human genome to health" [PubMed]

M. Rosenfeld et al., "GHK peptide prevents sleep-deprived learning impairment in aging mice" [PubMed]

M. Tucker et al., "Intranasal GHK peptide enhances resilience to cognitive decline in aging mice" [PubMed]

DISCLAIMER

This product is intended for laboratory research and development use only. It is not a medicine or drug and has not been approved by the FDA or EMA to prevent, treat, or cure any medical condition. Bodily introduction into humans or animals is strictly prohibited. This product must be handled by qualified professionals.

All information provided is for educational and informational purposes only.