IPAMORELIN - 5mg

SPECIFICATIONS

Product Code: IPM005

Sequence: H-Aib-His-D-2-Nal-D-Phe-Lys-NH2

Molecular Formula: C38H49N9O5

Molecular Weight: 711.40 g/mol

CAS: 170851-70-4

Purity: Technical / Research Grade 99%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

Ipamorelin is a synthetic pentapeptide belonging to the class of growth hormone secretagogues, characterized by its selective agonist activity at the ghrelin receptor (GHS-R1a). It is structurally related to other peptides within the same class but is distinguished by its receptor selectivity profile in experimental models. 

In research environments, ipamorelin is studied for its interaction with receptor-mediated signaling pathways associated with endocrine regulation and pituitary communication processes. Its activity is linked to ghrelin receptor signaling mechanisms involved in system-wide physiological coordination. Ipamorelin is also investigated for its role in modulating signaling interactions between neuroendocrine pathways, contributing to research focused on regulatory processes governing hormonal communication and integrative system responses.

At the molecular level, activation of GHS-R1a receptors by ipamorelin initiates intracellular signaling cascades associated with cellular communication, regulatory coordination, and endocrine system signaling.

Due to its selective receptor activity and well-characterized signaling profile, ipamorelin remains a relevant compound in experimental models exploring growth hormone–related pathways and neuroendocrine regulatory mechanisms.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

N.B. Andersen et al., "The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats" [PubMed]

A. Giustina et al., "Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human" [PubMed]

D.E. Beck et al., "Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients" [PubMed]

K. Raun et al., "Ipamorelin, the first selective growth hormone secretagogue" [PubMed]

J.V. Gobburu et al., "Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers" [PubMed]

J. Svensson et al., "The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats" [PubMed]

R.G. Gondo et al., "Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor" [PubMed]

M.M. Fowkes et al., "Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor" [PubMed]

B. Greenwood-Van Meerveld et al., "Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus" [PubMed]

E. Adeghate et al., "Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats" [PubMed]

P.B. Johansen et al., "Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats" [PubMed]

D.K. Sinha et al., "Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males" [PubMed]

V. Mericq et al., "Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children" [PubMed]

DISCLAIMER

This product is intendend for lab research and development use only. These studies are performed outside of the body. This product is not medicines or drugs and has not been approved by the FDA or EMA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.

INDEPENDENT THIRD-PARTY CERTIFICATE OF ANALYSIS SHOWN FORREFERENCE PURPOSES. ANALYTICAL RESULTS MAY VARY SLIGHTLY BETWEEN BATCHES.