VIALOX - 30ml/200mg

ADVANCED DELIVERY SYSTEM - STRUCTURED CARRIER TECHNOLOGY

This product utilizes a structured topical delivery architecture integrating membrane-interactive carrier matrices with controlled CPP-assisted transport modulation. The formulation is engineered according to the physicochemical profile of the research compound to support membrane interaction, diffusion behavior, and preservation of molecular integrity.

SPECIFICATIONS

Product Code: VIA200T

Sequence: H-Gly-Pro-Arg-Pro-Ala-OH

Molecular Formula: C21H36N8O6

Molecular Weight: 496.6 g/mol

PubChem CID: 11547785

Purity: Technical / Research Grade ≥98%

Form: Liquid Solution

Appearance: Clear to slightly opalescent

Total Content: 30 mL / 200 mg

Concentration: 6.66 mg/mL

Vehicle / Carrier System: Proprietary carrier system

Storage Temperature: 4°C (Do not freeze)

Source: Synthetic

Safety Classification: Standard laboratory handling

DESCRIPTION

Skin appearance is influenced not only by dermal matrix composition and collagen density, but also by the repetitive mechanical forces generated by facial expression muscles. Dynamic wrinkles develop over time as a result of continuous micro-contractions that mechanically fold the overlying skin.

Vialox is a synthetic pentapeptide investigated in cosmetic research for its interaction with peripheral nicotinic acetylcholine receptors (nAChRs) located at the neuromuscular junction.

Neuromuscular Signaling in Facial Skin

Facial expression depends on communication between motor neurons and muscle fibers. When acetylcholine (ACh) binds to nicotinic receptors, muscle contraction occurs. Repeated activation of this signaling pathway produces mechanical strain in the overlying dermal tissue. This mechanical stress contributes to:

• Formation of expression lines
• Crow’s feet development
• Forehead dynamic lines
• Glabellar folds
• Perioral micro-wrinkles

Cutaneous Mechanical Stress and Dermal Remodeling

Mechanical tension influences extracellular matrix (ECM) organization, affecting:

• Collagen fiber orientation
• Elastin integrity
• Glycosaminoglycan distribution
• Matrix metalloproteinase (MMP) activity

Excessive micro-contraction may accelerate dermal matrix fatigue, contributing to visible wrinkle formation.

Mechanistic Profile

Vialox has been studied as a competitive modulator of peripheral nicotinic acetylcholine receptors. By interacting with receptor binding sites, it may reduce acetylcholine-mediated signaling efficiency at the neuromuscular interface.

Reduced signaling intensity may decrease repetitive micro-contraction amplitude in superficial facial muscles.

Superficial Neuromodulation Concept

In cosmetic research, localized modulation of superficial muscle tension is associated with:

• Smoother skin surface appearance
• Reduction in dynamic wrinkle depth
• Improved skin texture
• Softening of expression-related folds

Dermal Microenvironment Interaction

When mechanical tension decreases:

• Fibroblast mechanical stress is reduced
• Matrix remodeling stabilizes
• Collagen degradation signaling may decrease
• Elastic fiber distribution becomes more uniform

This biomechanical stabilization supports improved visual skin smoothness.

Expression Wrinkle Biology

Dynamic wrinkles arise from repeated muscle movement, while static wrinkles result from intrinsic matrix degradation. Vialox is investigated within cosmetic research as an expression-modulating peptide.

Epidermal Surface Effects

• Improved epidermal uniformity
• Reduced fine-line visibility
• Enhanced surface smoothness

Cosmetic Observational Context

Topical application studies have reported improvements in wrinkle appearance and skin roughness parameters over a 28-day period. These observations are associated with reduced contraction-mediated mechanical stress.

Integrated Cosmetic Research Framework

The appearance of smoother skin is influenced by:

• Reduced contraction amplitude
• Balanced dermal tension
• Stabilized extracellular matrix
• Improved surface texture

Vialox is studied as part of a biomechanical modulation approach to skin appearance research.

Research Scope

This product is intended exclusively for laboratory and cosmetic formulation research. It is not intended for medical use.

REFERENCES

D. Servent et al., "Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor" [PubMed]

G. Mourier et al., "Chemical engineering of a three-fingered toxin with anti-alpha7 neuronal acetylcholine receptor activity" [PubMed]

D. Servent et al., "Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors" [PubMed]

S. Dutertre et al., "Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms" [PubMed]

I.E. Kasheverov et al., "Naturally occurring and synthetic peptides acting on nicotinic acetylcholine receptors" [PubMed]

V. Tsetlin et al., "Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors" [PubMed]

DISCLAIMER

This product is intended for laboratory research and development use only. It is not a medicine or drug and has not been approved by the FDA or EMA to prevent, treat, or cure any medical condition. Bodily introduction into humans or animals is strictly prohibited. This product must be handled by qualified professionals.

All product information provided is for informational and educational purposes only.