N-ACETYL SELANK AMIDATE - 30mg

SPECIFICATIONS

Product Code: NAS030

Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂

Molecular Formula: C35H60N12O9

Molecular Weight: 792.46 g/mol

CAS: 129954-34-3

Purity: Technical / Research Grade 100%

Other details: No TFA Salt

Form: Lyophilized powder

Color: White

Storage temperature: -20°C

Source: Synthetic

Safety classification: Standard handling

DESCRIPTION

Selank was developed alongside the nootropic peptide Semax at the Institute of Molecular Genetics of the Russian Academy of Sciences, in collaboration with the V. V. Zakusov Research Institute of Pharmacology. Selank has been studied in research contexts related to generalized anxiety disorder (GAD), cognitive performance, and stress modulation.

Selank is a synthetic peptide structurally related to the endogenous immunomodulatory peptide tuftsin. Experimental research indicates that Selank influences serotonin metabolism and is associated with reductions in anxiety-related behaviors.

Anxiolytic and Nootropic Properties

Selank belongs to the class of anxiolytic and nootropic compounds and has been studied in experimental and clinical research for its association with cognitive performance and emotional regulation. Research suggests associations with improvements in memory, learning capacity, and overall cognitive function, alongside reductions in anxiety-related symptoms in research models.

Unlike conventional anxiolytics such as benzodiazepines, Selank has been investigated for its lack of sedative effects, absence of cognitive impairment, and minimal dependence or withdrawal phenomena in experimental observations.

Neurochemical and Immune-Related Mechanisms

Experimental studies suggest that Selank influences serotonin metabolism, modulates monoamine neurotransmitter levels, regulates interleukin-6 (IL-6) expression, and alters the balance of T-helper-cell-associated cytokines. These findings support its classification as a peptide with both neurochemical and immunomodulatory research relevance.

Serotonin (5-hydroxytryptamine, 5-HT) is involved in cognition, reward, learning, memory, vasoregulation, and multiple physiological processes. Selank’s interaction with serotonin-related pathways has been central to research exploring its anxiolytic and cognitive effects.

Inflammation, Anxiety, and Asthenic Conditions

Research in individuals presenting depressive or anxiety-related symptoms suggests associations between Selank administration and reduced IL-6 gene expression. These observations have positioned Selank in research examining anxiety-asthenic conditions characterized by fatigue, headaches, palpitations, elevated blood pressure, neuropathic pain, and depressive features.

Comparative studies indicate anxiety-reducing effects similar to benzodiazepines, alongside modulation of enkephalin metabolism and inflammatory signaling pathways.

Cognition, Memory, and Brain Injury Research

An inverse relationship between anxiety and cognitive performance has been widely documented. Research suggests Selank may exert direct cognitive-supporting effects beyond anxiety modulation. In animal models, Selank administration following neurotoxic exposure has been associated with restoration of memory and learning performance, potentially through modulation of catecholaminergic pathways.

BDNF and Neuroplasticity

Experimental studies indicate that Selank is associated with increased expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. BDNF plays a critical role in neuronal survival, synaptic plasticity, neurogenesis, and long-term memory formation.

Research-Associated Effects of N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is a chemically modified form incorporating N-acetylation and C-terminal amidation. Research has examined this modified form in relation to:

• Reduction of emotional tension and anxiety-related behaviors
• Support of memory processes and information recall
• Enhancement of attention and reduced mental fatigue
• Support of learning capacity and cognitive adaptability
• Immune-related signaling modulation
• Regulation of monoamine neurotransmitter levels
• Increased BDNF expression
• Regulation of T-helper cytokine balance and IL-6 expression
• Investigation in experimental models relevant to alcohol withdrawal

Peptide Modifications: N-Acetylation and Amidation

N-acetylation is a modification used in synthetic peptide chemistry to alter molecular charge and hydrophobicity, potentially influencing stability and receptor interaction. Amidation affects the C-terminal region of peptides and may enhance resistance to proteolytic degradation and improve receptor binding affinity, contributing to prolonged biological activity.

REFERENCES

All observations described above originate from in vitro systems, animal studies, or other preclinical experimental models. They are intended solely to support basic research into molecular, cellular, and physiological mechanisms and do not imply therapeutic, diagnostic, or preventive applications in humans or animals.

A. Volkova et al., “Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission” [PMC]

I. I. Kolovskii et al., “The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats” [PubMed]

A. Kasian et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats” [Behavioural Neurology]

A. A. Zozulya et al., “The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity” [PubMed]

O. N. Uchakina et al., “Immunomodulatory effects of selank in patients with anxiety-asthenic disorders” [PubMed]

A. A. Zozulia et al., “Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia” [PubMed]

T. P. Semenova et al., “Experimental optimization of learning and memory processes by selank” [PubMed]

T. P. Semenova et al., “Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny” [PubMed]

DISCLAIMER

This product is intended for laboratory research and development use only. These studies are performed outside of the body. This product is not a medicine or drug and has not been approved by the FDA or EMA to prevent, treat, or cure any medical condition, ailment, or disease.

Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals.

All product information provided on this website is for informational and educational purposes only.

INDEPENDENT THIRD-PARTY CERTIFICATE OF ANALYSIS SHOWN FORREFERENCE PURPOSES. ANALYTICAL RESULTS MAY VARY SLIGHTLY BETWEEN BATCHES.